Unravelling the impact of hepatic IL-6 resistance on macrophage programming (P09)

• Subject Area: Immunology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

Chronic increased IL-6 levels in obesity lead to the development of hepatic IL-6 resistance where hepatocytes are unable to react to IL-6 signaling. Our data reveal that hepatic IL-6 resistance programs macrophages via hepatocyte-derived CSF-1 and IL-33, but the molecular consequences remain unknown. We have developed genetic mouse models to induce and prevent hepatic IL-6 resistance. Using these mice, we will investigate the impact of hepatic IL-6 resistance on macrophage programming with metabolic experiments and cell type-specific gene expression under dietary intervention.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Frank Thomas Wunderlich