Developmental programming of hepatic tissue-resident macrophages by maternal high-fat diet (P08)

• Subject Area: Immunology ; Developmental Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

This project will characterize intergenerational effects of maternal obesity on the development and function of hepatic macrophages, and how this modulates liver metabolism in the offspring. We aim to dissect the ontogeny, as well as cellular and molecular changes of macrophages, and other myeloid cells in the liver from the offspring born to obese mice. We will further characterize potential epigenetic modulators and lipid species that drive developmental programming events, and we aim to test whether the systemic metabolic changes in the offspring lead to detrimental effects in tissue regeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professorin Dr. Elvira Mass