Low Power Radiofrequency-Induced Release of Small Molecules from Iron Oxide-Polymer Core-Shell Composite Nanoparticles

• Applicant: Dr. Emilia Izak-Nau
• Subject Area: Solid State and Surface Chemistry, Material Synthesis
• Term: from 2020 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 447456398

The overarching goal of the project is to establish a Radiofrequency (RF)-triggered small molecule release system based on a mechanicalagitation of polymer shells of RF-sensitive Fe3O4 NPs. Within the scope of this research project, this aim will be pursued by followingthree major objectives: Objective 1: Formation of iron oxidecore/ polymer-shell NPs of different size and polymer immobilization strategy as nanocarriers for different drugs/molecules. Objective 2: Understanding the mechanical response and stability of the polymer coating in response to RF. Objective 3: Investigation of the drug/molecule loading capacity and rate of drug/molecule release from the variety of prepared nanocarriers under applied RF.

• DFG Programme: WBP Position