Project Details
Projekt
P4: Transcriptome, hepatic function, regeneration after (e)PHX and gut microbiome
Applicant
Professorin Dr. Manja Marz
Subject Area
General and Visceral Surgery
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 436883643
The Research Unit QuaLiPerF aims to enhance the understanding of the quantitative and spatial relationship between hepatic perfusion ad function in healthy, steatotic and regenerating livers using a systems surgery approach. P4 will focus on analyzing the transcriptome differences of healthy liver (WP A, F), steatotic liver (WP A, F), venous ligated liver lobe (WP C, F) and during regeneration (WP D). For each liver condition, we specifically distinguish spatial information between perivenous and periportal liver. The observed genes (with a focus on non-coding RNAs and isoforms) serve as potential marker genes for regeneration capacity and potential therapeutic targets. The results of this project will be input for the metabolic and multiscale computational models generated in QuaLiPerF (P3, P5, P7, P8) to limit the parameter space of the PDE and ODEs to describe the function and perfusion restricted liver more accurately. Finally, we will make first steps in analyzing the difference of the gut microbiome of healthy human and steatotic liver patients.With this project we contribute essentially to the understanding of the liver perfusion and function, which is the ultimate goal of QuaLiPerF.
DFG Programme
Research Units
