Towards clinical application of virtual deep brain stimulation (B01)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

We offer a dynamic multiscale modeling perspective on deep brain stimulation (DBS) to investigate its mechanisms, thereby creating new testable hypotheses, and providing an in silico testing ground for novel stimulation paradigms using The Virtual Brain (TVB). We plan to continue to enhance our developed and tested Virtual DBS model based on brain network modeling using our newly developed advanced parameter learning methods for the DBS optimization. We also aim to tackle the same optimization problem from a theoretical perspective applying methods from network and control theory. We plan to perform a first prospective pilot study of testing the simulation-assisted TVB-based electrode settings as a steppingstone toward bringing Virtual DBS modeling into clinical practice.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Jil Mona Meier, Ph.D.; Professorin Dr. Petra Ritter