Regulation of chromatin accessibility by Tbx factors guiding embryonic cell lineage specification (A08*)

• Subject Area: Developmental Biology ; Human Genetics
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

Cell identities are established during embryonic development and maintained throughout life. We demonstrated that the first specification event that segregates neuroectoderm from mesoderm and endoderm lineages is regulated by the Tbx transcription factors Eomes and Brachyury. We will analyse the dynamic changes in chromatin state during early exit from pluripotency and characterise the role of Eomes and Brachyury for recruitment of chromatin remodelling activities. This project aims at understanding the establishment of discrete cell lineage identities during the first lineage decision of early mammalian development.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Sebastian J. Arnold, since 7/2020