Biomarkers of disease states, adaptive stimulation and mechanisms of disease modification by deep brain stimulation in a progressive rodent model of Parkinson's disease (A01)

• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Previous work revealed that distinct pathostates require state-specific neuromodulation to have a disease-modifying effect in Parkinson’s disease (PD). During the second funding period project A01 aims to identify state-specific bio- and physio-markers, identify the compensatory mechanisms which prevent motor dysfunction despite neurodegeneration in early disease states, and develop state-specific neurostimulation which enhances these compensatory mechanisms. Together this work will enable stratification of PD patients by pathostates and implementation of state-specific neurostimulation to halt PD progression in all disease states.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Chi Wang Ip; Professorin Rhonda McFleder, Ph.D.; Professor Dr. Jens Volkmann