Hepatic TH signalling in acute and chronic liver injury (P18)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

This project studies local TH action in acute and chronic liver injury due to noxae. In a mouse model of acute liver failure, acute T3 treatment increased tissue damage while abrogation of TRß action was hepatoprotective. Furthermore, T3 treatment of mice with chronic alcoholic liver disease led to increased steatosis, which appeared to be due to remote indirect TH effects in white adipose tissue. These indirect effects possibly explain low response rates to the TH analogue resmetirom in some patients and expand our concept of local TH action. In the next funding period, results from mouse and cell models will be refined and translated into the human situation in iPSC-derived hepatocyte-like cells and samples of patients with acute liver failure and alcoholic liver disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Christian Lange; Professor Dr. Lars Möller; Dr. Denise Zwanziger