Impact of liver-specific TH activity on modulation of NAFLD and NASH (P15)

• Subject Area: Gastroenterology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

We aim to define the effects of local TH availability and efficacy in the liver in different cell compartments during progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) and liver fibrosis. We will provide profound phenotypic, spatial and functional analyses including samples of a human cohort, iPSC derived cells as well as appropriate rodent models and a perfusable liver-on-a-chip system to improve our understanding of TH-dependent mechanisms driving or reversing metabolic injury, inflammation and fibrogenesis. Based on our findings we will be able to identify novel disease stage- and cell-type-dependent drug targets modulating TH actions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Knut Mai; Dr. Tobias Püngel; Professor Dr. Joachim Spranger, until 6/2024; Professor Dr. Frank Tacke, Ph.D.; Dr. Eva K. Wirth, until 6/2024