Local TH action in acute and chronic ischaemic heart disease (P10)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

Modulation of cardiac TH/TR alpha signaling reduces infarct size ex vivo and in vivo. Furthermore, we have shown that timing of TH action is a crucial determinant in ischaemic heart disease, maladaptive hypertrophy and development of heart failure. Since our projects aims to exploit spatiotemporal TH action for improved outcome in heart diseases, we will now clarify the cell-specific contribution of endothelial cells (EC) and cardiomyocytes (CM) in myocardial infarction and will define the optimal time window to improve long-term infarct outcome. Moreover, we will test the hypothesis that posttranslational modifications (PTM) control local TR alpha signaling and propose PTMs as a new regulatory principle for fine-tuning canonical vs. non-canonical TH action in the cardiovascular system.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professorin Dr. Dagmar Führer-Sakel; Professorin Dr. Kristina Lorenz; Professor Dr. Lars Möller