Role of mitochondria in the regulation of myeloid cell function in skin homeostasis and repair (B10)

• Subject Area: Dermatology ; Immunology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

In the previous funding phase, we showed that mitochondrial metabolism coordinates the stage-specific activation and effector functions of macrophages to ensure effective wound healing in the skin. Based on our findings, we propose in the next funding period to further unravel the molecular signals that mediate the dynamics of mitochondrial metabolism and to decipher how metabolic rewiring is linked to macrophage function over the time course of wound healing. The long-term goal of this project is to understand how mitochondrial metabolism in macrophages regulates tissue repair and ultimately advance the development of therapeutic approaches to improve wound healing disorders in patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Sabine Eming