Effect of Bcl-2 proteins on mitochondrial structure, dynamics and function (A09*)

• Subject Area: Biophysics ; Cell Biology
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

The proteins of the Bcl-2 family are critical regulators of the mitochondrial pathway of apoptosis. Besides this function, evidence suggests that the Bcl-2 proteins have additional functions on several mitochondrial processes which, together with the molecular mechanisms involved, remain poorly understood. The main goal of this proposal is to dissect the differential role of the Bcl-2 proteins in mitochondrial organization and function and to uncover the underlying molecular mechanisms.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Ana Jesús Garcia Sáez