Interventional Treatment and Molecular Imaging of Coronary and Myocardial Inflammation by Magnetic Resonance Imaging (C15+ (P15))

• Subject Area: Medical Physics, Biomedical Technology ; Cardiology, Angiology
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 422681845

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed pla¬ques in a pig model. Furthermore, P15 will characterise downstream myocardial inflammation and its heterocellular interactions after MI, caus¬ed by catheter-based coronary artery occlusion. These tools will be used to explore temporal progression of in vivo lesion dynamics and of res¬ponses to intervention.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1425: Heterocellular Nature of Cardiac Lesions: Identities, Interactions, Implications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Michael Bock; Privatdozent Dr. Timo Sebastian Heidt; Professor Dr. Constantin von zur Mühlen