Interaction of macrophages with cell matrix niches in lymphoid organs (A12*)

• Subject Area: Immunology
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054

Lymphoid follicles within secondary lymphoid organs are anatomically delineated by biological barriers formed by specialized stromal endothelial cells. We previously observed that CD169+ macrophages interact with the stroma in these barriers. We aim to decode the molecular pathways defining these macrophage-stromal cell interactions and their impact in the specific immune responses to blood- and lymph-borne pathogens.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1009: Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
• Applicant Institution: Universität Münster
• Project Head: Dr. Noelia Alonso Gonzalez