The evolution of regulated necrotic cell death (B06)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

RCD pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. This project builds on own previous results and expands on the inter-phylum comparison of cell death pathways. The central goal of this project is to understand how different necrotic signalling pathways evolved from a pre-existing set of ancient protein modules and later added lineage-specific sub-pathways leading to their functional diversification.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Kay Hofmann