Ferroptosis and regulated cell death in sulphite oxidase deficiency (A08)

• Subject Area: Biochemistry ; Molecular Biology and Physiology of Neurons and Glial Cells ; Cell Biology
• Term: from 2020 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

Sulphite oxidase deficiency (SOXD) and molybdenum cofactor deficiency (MoCD) are autosomal recessive inborn errors of metabolism characterised by neurodegeneration and death in early childhood. The underlying molecular mechanisms leading to neuronal cell death and tissue degeneration are poorly understood. This project will investigate the role of ferroptosis and other pathways of regulated cell death (RCD) in the pathogenesis of SOXD, and address the underlying mechanisms using disease models for the patient phenotype aiming to develop treatments that target cell death pathways in both disorders.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Günter Schwarz