Specificity of proteasome regulation by tail-anchored transcription factors (A07)

• Subject Area: Organismic Interactions, Chemical Ecology and Microbiomes of Plant Systems
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 232631280

The proteasome is involved in plant defence and is therefore exploited by pathogens. We have shown that the transcription factors NAC53/78 (i) regulate proteotoxic stress during bacterial infection, are essential for plant defence, and are degraded by the proteasome. We aim to elucidate (i) which other target genes are regulated by NACs, (ii) by which factors NACs are posttranslationally regulated, (iii) how subcellular sorting of NACs functions, and (iv) how NACs specifically modulate target genes. This should decipher how NACs integrate different signals to balance the trade-off between proteasome regulation and defence.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1101: Molecular Encoding of Specificity in Plant Processes
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Head: Professor Dr. Suayib Üstün