Checkpoints determining recovery from acute autoimmune CNS grey matter lesions (A03)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537

This project focuses on recovery mechanisms of the CNS tissue in the course of acute T-cell mediated autoimmune inflammation. We hypothesize that T-cell induced changes of the grey matter are crucial for the failing recovery of the CNS after repeated autoimmune bouts and that lung microbiota are external regulators of de- and regenerative processes within the CNS tissue. We aim to identify brain-resident and peripheral targets to prevent permanent CNS damage and/or to foster its recovery which might in perspective be exploited to develop novel therapeutic strategies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 274: Checkpoints of Central Nervous System Recovery
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Alexander Flügel