Project Details
Projekt
Decoding of crescent fate in an integrative and translational approach (B09)
Subject Area
Nephrology
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542
In this third funding period, we aim to characterize the potential for cellular crescent resolution and define glomerular subsets that are most likely to recover and those that are unlikely to respond to therapy based on an integrative multiscale mapping of the key signaling pathways involved in crescent resolution and loss in experimental and human RPGN. Overall, this project will shed light on a central aspect in the management of RPGN, which has the potential to directly impact patient stratification (i.e. risk status), establish “molecular windows” for current medication and broaden the spectrum of therapeutic options, paving the way to an individualized medicine in patients affected by RPGN.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1192:
Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
Applicant Institution
Universität Hamburg
