Proteolytic modulation of intestinal CD4 T helper cell function and immune homeostasis (B15#)

• Subject Area: Immunology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

We will analyze the role of ADAM10/17/Notch activation in mouse and human intestinal Thcells. We focus in particular on the molecular regulation of IL-22 and its anti-inflammatoryand regenerative functionality. We will identify signaling pathways and transcriptionalprograms that regulate IL-22 expression and memory. In a new human-relevant model ofcommensal C. albicans colonization in mice, we investigate the role of ADAM & Notch andIL-22 in the antigen-specific regulation of mucosal homeostasis and inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professor Dr. Alexander Scheffold