The neglected receptor N terminus - signal filter, signal integration, trans-signaling of adhesion GPCR (C04)

• Subject Area: Biochemistry ; Pharmacology ; Cell Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 421152132

Adhesion GPCR are unique receptors as they can flexibly elicit several functions such as adhesion, classical signals into cells via G-protein pathways (cis), and also so-called trans functions onto opposing cells. The integration of all these functions is realized by the receptors´ large and complex N termini via several means such as different receptor variants and ligands. Using the prototypic aGPCR Latrophilin in the simple model organism C. elegans, this project delineates the dynamics and spatial-temporal requirements of variants, receptor cleavage and ligand-binding on receptor activity as well as on cis and trans function. Furthermore, it will dissect their interplay to understand how they enable the N terminus to coordinate the numerous receptor functions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1423: Structural Dynamics of GPCR Activation and Signaling
• Applicant Institution: Universität Leipzig
• Project Heads: Professorin Dr. Simone Prömel; Professor Dr. Torsten Schöneberg