Project Details
Projekt
Task-dependent Orchestration of Insect Olfactory Sensory Neuron Performance
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2020 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 430156010
Sensory systems have to provide an appropriate representation of the environment. What is appropriate depends on the meaning of a signal for the organism. In the proposed project we investigate the tuning of insect odorant receptors. Olfactory sensory neurons expressing the receptor Or56a which detects the alarm odor geosmin, a product of toxin producing microbes, are permanently tuned to highest sensitivity. By contrast, cells expressing the food odor-detecting Or22a are set to moderate sensitivity under resting conditions but can be sensitized on demand. The aim of this project is to investigate how these different properties in sensory neuron performance are realized and manifested at various levels, such as odorant receptor expression density, downstream signal processing and amplification within the compartments of the receptor neuron. The comparative approach will target the olfactory signaling chain of Or22a and Or56a expressing olfactory sensory neurons at the various levels. For this sake we will apply super resolution fluorescence microscopy as well as the electrophysiological patch clamp technique.
DFG Programme
Priority Programmes
