Stress-induced modulation of reconsolidation-related memory network dynamics (B10*)

• Subject Area: Biological Psychology and Cognitive Neuroscience
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

This project aims at elucidating the impact of stress and major stress mediators on memory reconsolidation and the underlying brain networks. We predict that stress and glucocorticoid activation impair reconsolidation by interfering with the recruitment of and crosstalk in limbic, prefrontal and large-scale frontoparietal memory networks, whereas noradrenergic stimulation may have the opposite effect. In order to test these predictions, we will combine experimental stress-induction and pharmacological elevation of glucocorticoid and noradrenergic activity with funtional MRI recordings of memory network dynamics during encoding, reactivation and test.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Lars Schwabe