Dopaminergic control of dorsal hippocampal networks during behaviour (B08*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

How does the brain know what it has to remember and what it may safely forget? Dopamine is a central neuromodulator signaling salience and novelty and it is important for learning and memory formation. In this project we will investigate how dopamine controls network activity and functional connectivity in the dorsal hippocampus of mice during different behavioral states. Using two-photon imaging in the hippocampus during behavior in combination with optogenetic and chemogenetic manipulation of locus coeruleus and ventral tegmental area we aim at unravelling the specific roles of these long-range projecting areas for defined behavioral states and hippocampus-dependent learning and memory-formation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Jörn Simon Wiegert