Role of the cytokine midkine in neutrophil trafficking and myocarditis (B10*)

• Subject Area: Immunology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

In this project, we aim to delineate the mechanistic link between midkine (MK), its receptor low density lipoprotein receptor-related protein 1 (LRP1) and neutrophil extracellular traps (NETs) in myocarditis. Using a variety of state-of-the-art imaging technologies we will investigate the role of these factors for neutrophil trafficking and NET formation in myocarditis on the molecular, cellular and systemic level. These findings may allow a deeper understanding of neutrophil function in cardiac inflammation and may lead to novel therapeutic concepts for the treatment of myocarditis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Dr. Ludwig Thomas Weckbach