Adaptive remodeling of ribosome composition and function in response to metabolic changes and cellular stress (B06)

• Subject Area: Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

The ribosome is a large machinery that translates the genetic information into function. Originally considered to be an invariable entity of ribosomal proteins and rRNA that together with translation factors sustain protein synthesis, there is increasing evidence for ribosome heterogeneity that facilitates the dynamic amendment of protein synthesis and ribosome-associated processes to different metabolic and environmental conditions. We aim to study the modulation of ribosomal activity by association with different proteins and to analyse their role in the adaption of bacteria to adverse conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Hans-Georg Koch