Assembly, dynamics and function of ELAV protein machineries in neurons (B02)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

In Drosophila, the protein ELAV causes an extension of the 3’ UTR of hundreds of genes, exclusively in neurons. We will dissect the assembly and modular composition of the nuclear and cytoplasmic ELAV-containing ribonucleoprotein subcomplexes. We will focus on the formation of condensates by nuclear ELAV-subassemblies and also analyse the cellular consequences caused by targeted disruption of distinct subcomplexes to elucidate their physiological functions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Dr. Valerie Hilgers