Biogenesis and activity-dependent dynamics of AMPA-receptor complexes (A08)

• Subject Area: Biochemistry
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

Native AMPA-type glutamate receptors (AMPARs) are multi-protein complexes that reconsti-tute the receptor ion channels responsible for rapid signal transduction and memory formation in excitatory synapses of the mammalian brain. We will investigate the molecular steps behind assembly and processing of these multi-component machineries in the endoplasmic reticulum, analyze the structural details behind the complex assemblies, and study the significance of receptor dynamics for excitatory neurotransmission and its activity-dependent plasticity in the normal and diseased brain.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Bernd Fakler