Inflammatory and necroptotic signaling in SCLC (A04)

• Subject Area: Cell Biology ; Immunology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 413326622

M. Pasparakis and his team will deepen their studies on the role of inflammatory and necroptotic signaling in SCLC, using relevant GEMMs. Based on their findings from the first funding period, wherein tumor development depends on NF-B – but not TNFR1 – they will seek to address the role of NFkB as a therapeutic target in SCLC. They will employ dual recombinase approaches spearheaded by A01 to inactivate NEMO in established tumors in GEMMs to assess, whether established SCLC is dependent on continued activation of this inflammatory transcription factor. They will also seek to address, whether NF-B plays a role in MYC-driven SCLC, as well. In a complementary approach, they will also study the role of necroptosis in the tumor microenvironment in SCLC by means of genetic mouse models allowing to assess the role of ZBP1 activation and its regulation by Adar1.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1399: Mechanisms of drug sensitivity and resistance in small cell lung cancer
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Manolis Pasparakis