Genomic position matters– integrating comparative genomics and molecular evolution

• Applicant: Dr. Nora Hohmann
• Subject Area: Plant Genetics and Genomics
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424626686

The impact of chromosomal position on the evolution of genes is not well understood, and is a crucial but missing component of comparative genomics. In this project, I will address this significant gap in knowledge by investigating the interplay of chromosomal position and molecular evolution. I will use the “model” family Brassicaceae as a study system to approach this question, as they are particularly well suited for this application due to the abundance of high quality genome sequences. All Brassicaceae share an ancient whole genome duplication event, after which their respective genome sizes were reduced. Genetic traces of this duplication are still detectable. As duplicated genes play an important role in evolution and adaptation, this offers a unique research opportunity. I will include the sister family Cleomaceae with its own independent whole genome duplication event to expand my comparative framework. This will allow me to compare the different molecular evolutionary changes that occurred after these independent genome duplications. The aim of my project is to bring together information from whole genome sequences and varying rates of molecular evolution along the chromosomes in a phylogenetic context. My project will provide important insights into evolutionary patterns underlying the dynamic genomes of plants, as well as expand the existing comparative genomics framework beyond Brassicaceae, thereby creating a valuable resource for researchers and plant breeders alike.

• DFG Programme: Research Fellowships
• International Connection: Netherlands
• Host: Professor Dr. Eric Schranz