Resistance Mechanisms of glioblastoma against alkylating agents and radiotherapy (A06)

• Subject Area: Hematology, Oncology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

In this project we aim at identifying the effects of temozolomide on the single cell level, particularly its concentration per cell, its diffusion through the brain, and correlation of the effect with localization of the cell within the tumor. For that purpose, we employ the method to trace temozolomide on the single cell level which we have developed in the first funding period. This insight will reveal the heterogeneity of temozolomide effects within the tumor, intra-tumoral factors affecting its efficacy, and ultimately identify tumor cell type-specific targets to overcome resistance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Violaine Goidts, Ph.D.; Professor Dr. Felix Sahm