Project Details
Projekt
Targeting tumor cell network communication to overcome primary and adaptive resistance in glioblastoma (A01)
Subject Area
Hematology, Oncology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405
In this project we will further investigate tumor-autonomous communication in glioblastoma cell networks, a central discovery of the first funding period. A small subpopulation of tumor cells located in network hubs exerts periodic, rhythmic Ca2+ oscillations via the potassium channel KCa3.1, continuously activating the glioblastoma network and driving tumor growth. The specific aims are (1) to understand which glioma subtypes depend on this mechanism, (2) how it is influenced by standard therapies, and (3) how KCa3.1 inhibition can be used to break the network-related resistance of glioblastoma towards radio- and chemotherapy and surgical lesioning.
DFG Programme
Collaborative Research Centres
Major Instrumentation
Mikroskop für Lebendzell-Imaging
Instrumentation Group
5090 Spezialmikroskope
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Dr. Erik Jung, from 9/2019 until 12/2022; Dr. Matthias Osswald, until 8/2019; Dr. Sophie Weil; Professor Dr. Frank Winkler
