Co-stimulatory molecules as determinants of the acute immune response following cardiac ischemia reperfusion injury (B09)

• Subject Area: Cardiology, Angiology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

Co-stimulatory molecules are central for shaping immune responses yet their function following myocardial infarction is not determined. Here, we will test the contribution of two co-stimulatory pathways, namely the CD40/CD40L and CD27/CD70 axes, to morphological and functional outcomes after myocardial infarction in mice. We will examine the cell type-dependent expression and function of these factors determining the immune reaction after recovery from cardiac ischemia/reperfusion injury in mice. By using genetic and pharmacological inhibition this project will help to understand the role of CD40/CD40L and CD27/CD70 following acute myocardial infarction.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Norbert Gerdes