Vascular control of adipose tissue and muscle in the context of obesity and cancer (C04)

• Subject Area: Cardiology, Angiology ; Hematology, Oncology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046768

Project C04 aims at systematically unravelling how cancer changes endothelial heterogeneity, the angiocrine signaling landscape and at deciphering how angiocrine signaling contributes to tissue wasting during tumor progression. The group will towards this end (i) explore how the presence of a solid tumor mass at distant sites changes endothelial cell heterogeneity in white adipose tissue (WAT), (ii) decipher cachectokines which mediate the critical long-distance cancer-endothelial cell crosstalk inducing endothelial Notch signaling, (iii) characterize changes in muscle tissue, (iv) determine potential angiokines responsible for muscle wasting, and (v) determine the functional relevance of such angiokines.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1366: Vascular Control of Organ Function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Andreas Fischer