Hepatovascular control of disease susceptibility and resistance via circulating blood factors (B03)

• Subject Area: Cardiology, Angiology ; Gastroenterology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046768

The group has shown during the first funding period that clearance of the peripheral blood by liver endothelial cells determines disease susceptibility and resistance. Deficiency of either Stab1 or Stab2 as well as anti-Stabilin monoclonal antibodies provide protection from atherosclerosis. Project B03 will elucidate the underlying molecular events including downstream processes of vesicular transport and cytoskeletal dynamics and assess the role of Stab1/Stab2 in immune complex diseases. Overall, hepatovascular clearance will be scrutinized to identify opportunities for targeted adjustments of the plasma proteome for preventive and therapeutic applications.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1366: Vascular Control of Organ Function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Cyrill Géraud