Renoprotective role of Angiotensin-(1–7) (B06)

• Subject Area: Nephrology ; Endocrinology, Diabetology, Metabolism
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

The ACE2/Angiotensin (Ang)-(1-7)/Mas axis of the renin-angiotensin system may play an important role in renal diseases. Therefore, we will study the expression of components of this axis and the signaling pathways of Ang-(1-7) and Mas in different renal cell types. Moreover, we will generate transgenic animal models with targeted dysregulation of this axis in defined renal cell types. We will expose these animals to renal disease models and will analyse renal function and damage using state-of-the-art physiological, histological and imaging technologies. As a first step into translation of these results, we will use newly developed orally available Mas agonists for the preclinical evaluation of therapies for renal diseases based on the ACE2/Ang-(1-7)/Mas axis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Natalia Alenina, Ph.D.; Professor Dr. Michael Bader