Lipid dependence of signaling at curved membrane microcompartments (P22*)

• Subject Area: Biochemistry
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 180879236

Project P22 will investigate how changes in membrane properties affect signaling at curved plasma membrane microcompartments in vertebrate cells. To determine the membrane contribution to curvature-dependent signaling, the group aims to characterize (i) how changes in lipid composition affect biophysical membrane properties such as microviscosity, rigidity or tension, (ii) how changed membrane properties influence curvature-dependent protein dynamics, and (iii) how changes in curvature-dependent protein recuitment regulate cell signaling and function.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 944: Physiology and Dynamics of Cellular Microcompartments
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Milos Galic