Project Details
Projekt
Functional characterization of novel mechanisms regulating SERCA activity and Ca2+ homeostasis in D. melanogaster (P21*)
Subject Area
Cell Biology
Term
from 2019 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 180879236
The project P21 focuses on the mechanistic understanding of a novel process that regulates activity of the calcium ATPase (SERCA) within Ca2+ uptake membrane microdomains of the sarcoplasmic reticulum of flies. Impaired activity of the metalloprotease Nep4 significantly affected cardiac Ca2+ homeostasis and induced a strong arrhythmia phenotype. To understand the molecular mechanisms underlying the Nep4 mediated regulation of SERCA, they will (i) identify phenotype-relevant Nep4 peptide substrates, (ii) analyze the suborganellar localization, and (iii) determine the funciton and dynamics between Nep4 and SERCA in detail.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Osnabrück
Project Head
Dr. Heiko Harten
