The NLRP3 inflammasome in CNS homeostasis and disease (A08)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: from 2019 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

The NLRP3 inflammasome is a major instigator of disease-associated inflammation and immunepathology in many tissues including the CNS. However, little is known about the role of NLRP3 inmaintaining homeostasis. Combining murine ex vivo CNS culture systems, in vivo models of resolvingneurological injury, and inducible genetic models of activating NLRP3 patient mutations, we willcharacterize NLRP3 activation and its consequences in complex CNS tissue and study the earlyevents of pathogenesis of NLRP3-driven neuroinflammation that might guide therapeutic interventionsin diseases such as Multiple Sclerosis and Alzheimer's disease or Parkinson's disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Olaf Groß