Prioritizing genes for kidney function decline in the population and high risk groups (C06)

• Subject Area: Nephrology ; Epidemiology and Medical Biometry/Statistics
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Genome-wide association studies (GWAS) and their meta-analyses (GWAMAs) are among the most successful approaches to identify genetic factors for multi-factorial diseases. Our overarching aim is the identification and characterization of the genetics of kidney function decline in general populations and high risk subgroups. Moreover, we will develop a systematic approach to join various kinds of information on “kidney genes” (e.g. condition- and disease-dependent gene and protein expression, pathways and regulation) into a tool for GenePrioritiSation (GPS). This web-based searchable GPS tool will provide a comprehensive body of information to researchers of CRC 1350 and to the public.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Carsten A. Böger; Professorin Dr. Iris M. Heid