Complement-mediated crosstalk between tubular and interstitial cells in renal transplantation - focus on the lectin-activated pathway (C02)

• Subject Area: Nephrology ; Pathology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

In this project, we will comprehensively characterize the activation of the complement pathway, in particular of the lectin pathway, during renal transplantation, with specific focus on the crosstalk of renal tubular epithelial cells and inflammatory cells. For this, we will use human renal biopsies and renal tissue from experimental studies in rats. Using either an inhibitory antibody directed against the activator of the lectin-activated complement pathway MASP-2, or a C5-blocker inhibiting the terminal route of all complement pathways, we aim to target complement activation to prevent graft deterioration and graft loss. In addition, interaction of various complement factors with renal tubular cells will be investigated in vitro.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professorin Dr. Kerstin Amann; Dr. Maike Büttner-Herold; Professor Dr. Christoph Daniel