Assessment of the structure and function of the renal interstitium by intravital multiphoton microscopy (B02)

• Subject Area: Anatomy and Physiology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Little is known about the physiology of the renal interstitial compartment and how it might interfere with tubular and vascular functions. This project will address these questions using serial intravital multiphoton microscopy, which will allow us to visualize the dynamic changes of the composition of renal interstitial cells in real time and to study interstitial-tubular/vascular communication and its effect on renal function. Our previous findings indicate that interstitial cells are motile. In the context of a potential renal interstitial stem cell nice, we will further clarify the role of interstitial cell mobility in renal regeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Hayo Castrop; Dr. Ina Maria Schießl, until 1/2020