Low molecular weight proteinuria caused by a mutation of the Vesicle Associated Protein (VAP) (A07)

• Subject Area: Nephrology ; Anatomy and Physiology ; Cell Biology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

The project deals with a previously unknown autosomal recessive disease, in which a mutation in the gene of the "vesicle-associated protein" (VAP) leads to reduced protein uptake in the proximal tubule and to “low-molecular-weight” proteinuria. The role of VAP in the kidney is unknown and will be investigated with the help of genetically modified mice and cell models. The expected results will contribute to a better understanding of protein resorption in the kidney and provide insights into the pathogenesis and tubular signaling in this unknown disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Richard Warth