Mechanisms of early ciliogenesis (A01)

• Subject Area: Nephrology ; Nuclear Medicine, Radiotherapy, Radiobiology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Defects in primary cilia, singular extensions of almost all mammalian cell types, give rise to a wide variety of genetic diseases, including cystic kidney disease. Despite their great importance, it is virtually unknown by what mechanisms primary cilia are formed. Our own preliminary data provide sound evidence that endocytosed plasma membrane accounts for the early stages of ciliogenesis. In order to better understand this process, the underlying form of endocytosis and the intracellular trafficking pathway from the plasma membrane to the centrosome will be characterized in detail.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Ralph Witzgall