Regulation of tubular metabolism, senescence and renal regeneration by coagulation proteases in the context of diabetic kidney disease (B07)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Medical Informatics and Medical Bioinformatics
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

The „metabolic memory” is an unsolved medical problem. We postulate that (i) the metabolic memory is based on epigenetically fixed gene dysregulation with associated senescence, sterile inflammation, and reactive metabolites, and (ii) that these changes are controlled by endothelial dysfunction and an associated impaired signal transduction by coagulation proteases. Using innovative mouse models and methods, we intend to clarify the causal significance of epigenetically fixed senescence and its regula-tion by the coagulation system and, based on this, to identify new therapeutic targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Berend Isermann, since 7/2018