Role of mammalian histone variants H3.3 and H2A.Z in differentiation and disease (A15*)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 109546710

The main aim is to discover and functionally dissect the molecular mechanisms during differentiation and disease development of:A) DAXX-dependent H3.3-mediated silencing of heterochromatic genes and the chaperone dependence of H3.3K27M in tumor development, and B) the PWWP2A-interactome with a functional focus on the novel “core NuRD” and the proposed PHF14-RAI1-TCF20-HMG20A (PRTH) complexes in transcriptional regulation of PWWP2A-bound H2A.Z target genes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 81: Chromatin Changes in Differentiation and Malignancies
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professorin Dr. Sandra Brigitte Hake