Extracellular vesicles induced by innate immune pathways in cancer immunosurveillance (P14)

• Subject Area: Hematology, Oncology ; Immunology
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 360372040

Secreted extracellular vesicles (EVs) are emerging as an important mechanism of intercellular communication in the tumour microenvironment. Aberrant immune signalling pathways in tumour cells that regulate the biogenesis and often immunosuppressive function of such EVs remain unknown. Led by our recent discoveries about cancer-intrinsic roles of IFN-I-coupled pathways in modulation of cancer immunosurveillance, we here aim to understand the role of tumour-intrinsic cytosolic RIG-I and STING in the generation and function of immunogenic EVs to influence cancer immunosurveillance and -therapy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1335: Aberrant Immune Signals in Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Privatdozent Dr. Simon Heidegger; Professor Dr. Hendrik Poeck