Mitophagy during mitochondrial damage and cellular rejuvenation (F08 (D08))

• Subject Area: Biochemistry ; Anatomy and Physiology ; Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

Mitophagy is essential in maintaining mitochondrial homeostasis and preserving energy metabolism. This project builds up on the original observations that mitochondrial unfolding protein response is a potent inducer of mitophagy and that increased mitophagy is associated with cellular quiescence exit. The project will evaluate whether targeting mitophagy could serve as a novel strategy to manipulate cell cycle transition and senescent cell elimination in developing and aged tissues.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professorin Dr. Sofia Iris Bibli, Ph.D., since 1/2024; Professor Dr. Christian Münch