Project Details
Projekt
Radioimmunotherapy of pancreatic cancer: combining biologically augmented radiotherapy with multi-functional release of immune checkpoints (P16)
Subject Area
Gastroenterology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492
We will evaluate the therapeutic performance of combined modality radiation therapy with radiosensitizers and multi-functional antibody derivatives aimed at modulating innate and adaptive immune checkpoints. Radiosensitizing candidate drugs will be identified in screening approaches followed by mechanistic characterization. Basal and therapy-induced vulnerabilities in immune checkpoints will be examined and exploited using multi-functional antibody derivatives. Combinations of the most promising approaches will be analyzed in syngeneic transplantation models and investigated at the cellular, transcriptomics, and proteomics level.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1321:
Modelling and Targeting Pancreatic Cancer
Applicant Institution
Technische Universität München (TUM)
