Tissue-specific inflammation mechanisms induced by constitutive STING signaling in pediatric autoinflammatory disease with vascular inflammation (B18)

• Subject Area: Pediatric and Adolescent Medicine
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disease caused by gain-of-function mutations in the STING1 gene. In the STING N153S mouse model of SAVI, we will investigate whether constitutively active STING impairs hematopoiesis by perturbing hematopoietic stem/progenitor cells and the bone marrow stroma. Further, using a new mouse line with floxed STING N153S allele, we will clarify in which cell types STING N153S is required for the development of lung inflammation. Finally, we will determine why pregnant SAVI mice fail to carry a pregnancy to term. The project will contribute to a better understanding of SAVI and STING-related autoinflammation in general.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Dr. Angela Rösen-Wolff; Dr. Lino Lars Teichmann, since 1/2023